Moringa oleifera leaves alleviated inflammation through downregulation of IL-2, IL-6, and TNF-α in a colitis-associated colorectal cancer model

New chemopreventive alternatives are needed due to the rising worldwide incidence of colorectal cancer. The objective was evaluate activity Moringa oleifera leaves (MO) in a colitis-associated colon carcinogenesis model. We hypothesized that MO contain bioactive compounds capable modulating expression genes involved inflammatory response and carcinogenesis. Forty-eight male mice (CD-1) were divided into six groups; 1: Healthy control; 2: Positive control induced with azoxymethane (AOM, 10 mg/Kg body weight, intraperitoneal injection) three cycles dextran sodium sulfate (DSS, 1.5% drinking water); groups 3, 4, 5 AOM/DSS supplemented 5%, 10%, 20% MO, respectively; group 6: had no disease induction MO. Mice treated for 12 weeks euthanized. Significant differences (p < 0.05) found moringa-administered morphological histopathological parameters compared control. A decrease myeloperoxidase (~50%) lipid peroxidation (1.9–3.1 times) 10% 0.05). showed significant increase (~3 butyrate propionate fecal cecal content. Groups reduction proinflammatory cytokines serum (MCP-1, IL-6, TNF-α) Treatment differential 65 tissue such as IL-2, TNF, IL-1ß, INF-γ. downregulated mediators showing properties against